`\begin{tikzpicture}
\filldraw[red!20, rounded corners] (-1, -1) rectangle (4, 4) ;
\clip (1,0) -- (0,1)--(0,4)--(4,4)--(4,0);
\filldraw[blue, rounded corners, even odd rule] (0, 0) rectangle (3, 3) (1, 1) rectangle (2, 2) ;
\end{tikzpicture}` peut-être?